منابع مشابه
The Remarkable Stability of the Latent Reservoir for HIV-1 in Resting Memory CD4+ T Cells.
The modern era of antiretroviral therapy (ART) for human immunodeficiency virus type 1 (HIV-1) infectionbegan in the mid-1990s with the introduction of 2 new classes of antiretroviral drugs, the protease inhibitors (PIs) and the nonnucleoside reverse-transcriptase inhibitors. Combinations consisting of 1 of these drugs along with 2 nucleoside analogue reverse-transcriptase inhibitors rapidly re...
متن کاملHomeostatic proliferation of memory T cells and expansion of the HIV-1 latent reservoir
Methods We have developed a system whereby naïve cells from the peripheral blood of healthy donors are induced to undergo normal development ex vivo in the presence of the appropriate cytokine cocktails and antigenic stimulation through CD3/CD28. These cells are infected while in the activated state, and return to quiescence as central memory cells (TCM). Infection of these ex-vivogenerated mem...
متن کاملHIV-1 Infection of T Cells and Macrophages Are
The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck. However, the implication of this interaction for viral replication and infectivity in macrophages and T lymphocytes remains unclear. Experiments in HIV-1 infected macrophages confirmed the presence of a Nef:Hck complex which was dependent on the Nef proline repeat motif...
متن کاملPeripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection
Eradication of HIV infection will require the identification of all cellular reservoirs that harbor latent infection. Despite low or lack of CD4 receptor expression on Vδ2 T cells, infection of these cells has previously been reported. We found that upregulation of the CD4 receptor may render primary Vδ2 cells target for HIV infection in vitro and we propose that HIV-induced immune activation m...
متن کاملNumerical analysis of fractional order model of HIV-1 infection of CD4+ T-cells
In this article, we present a fractional order HIV-1 infection model of CD4+ T-cell. We analyze the effect of the changing the average number of the viral particle N with initial conditions of the presented model. The Laplace Adomian decomposition method is applying to check the analytical solution of the problem. We obtain the solutions of the fractional order HIV-1 model in the form of infini...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2016
ISSN: 1742-4690
DOI: 10.1186/s12977-016-0323-4